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鉴定M5c调节剂药物甲基化修饰模式,用于质瘤的预后和免疫微环境

Zhenyong Xiao¹, Jinwei Li^1,2, Cong Liang³

¹Department of Neurosurgery, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545000, Guangxi, China.

|November 7, 2023

概括

这项研究揭示了5-甲基氨酸 (m5C) RNA修饰在质瘤中至关重要,具有与m5C相关的新型特征,可以准确预测患者的生存率和免疫相关性.

科学领域:

在瘤学瘤学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
生物信息学是一种生物信息学.

背景情况:

质瘤是一种常见的大脑瘤,预后不好.
5甲基氨酸 (m5C) RNA修饰越来越多地被认为是它在瘤发生中的作用.
在质瘤中m5C的预后和免疫影响尚不清楚.

研究的目的:

研究质瘤中m5CRNA修饰的预后价值和免疫相关性.
为了识别关键的m5C相关基因,并构建一个预测的签名,质瘤的生存.

主要方法:

利用癌症基因组图谱 (TCGA) 和中国质瘤基因组图谱 (CGGA) 数据集用于RNA表达和临床数据.
采用非阴性矩阵因数分解 (NMF) 进行患者分组,使用CIBERSORT和ssGSEA进行免疫微环境分析,使用权重基因同表达网络分析 (WGCNA) 与Cox比例危险模型进行签名构造.

主要成果:

确定了大多数m5CRNA甲基化调节者的差异表达和预后意义.
确立了免疫细胞透和m5C调节器,特别是NSUN7.7之间明显的联系.
开发并验证了一种与m5C相关的基因特征 (SEPT3,CHI3L1,PLBD1,PHYHIPL,SAMD8,RAP1B,B3GNT5,RER1,PTPN7,SLC39A1,MXI1),可显著预测质瘤患者的生存率.

结论:

m5C RNA 修饰在质瘤的发展和预后中起着重要作用.
开发的m5C相关特征是预测质瘤患者存活率的强大工具.
了解m5C调节及其与免疫微环境的相互作用,为质瘤提供了潜在的治疗途径.

关键词:

通过RNA甲基化.在WGCNA中,WGCNA是WGCNA.质瘤质瘤是一种免疫微观环境免疫微环境 m5C 在线观看

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