在治疗艾滋病毒感染期间体重增加的临床后果
Andrew Hill1, Willem Daniel Francois Venter2
1Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
Current opinion in HIV and AIDS
|November 7, 2023
概括
杜鲁特格拉维尔是一种HIV整合酶抑制剂,在抑制病毒载荷方面表现出成功. 然而,新兴的研究表明与高血压存在潜在联系,尽管因果关系需要进一步调查,因为存在混因素.
科学领域:
- 艾滋病毒/艾滋病治疗治疗
- 抗逆转录病毒疗法是一种治疗方法.
- 艾滋病毒感染的心血管风险
背景情况:
- 口服整合酶抑制剂多卢特格拉维尔在公共卫生艾滋病毒计划中广泛使用,其表现出优异的病毒负载抑制,持久性和安全性.
- 关于免疫复合炎症综合征 (IRIS),神经管缺陷和与整合酶抑制剂相关的体重增加的先前担忧已在很大程度上得到解决.
- 关于潜在的心血管风险,特别是高血压和这种类型的抗逆转录病毒药物之间可能存在关联,出现了新的担忧.
结论:
- 需要进一步仔细分析,以确定多卢特格拉维尔和高血压之间的因果关系.
- 与体重增加信号类似,如果不进行更严格的调查,就无法确定确定的因果关系.
- 这一类抗逆转录病毒的潜在血压升高背后的生理机制尚不清楚.
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