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在艾滋病毒感染者中肥胖的发病因子

Samuel S Bailin¹, John R Koethe¹, Peter F Rebeiro^1,2,3

¹Department of Medicine, Division of Infectious Diseases.

Current opinion in HIV and AIDS

|November 7, 2023

概括

超重和肥胖对艾滋病毒 (PWH) 感染者来说越来越令人担忧,而抗逆转录病毒疗法 (ART) 则加剧了这种情况. 了解艾滋病毒,ART和肥胖之间的联系对于管理PWH的代谢并发症至关重要.

科学领域:

公共卫生公共卫生
传染性疾病传染性疾病
代谢综合征是代谢综合征的一种.

背景情况:

超重和肥胖是一个重大的公共卫生挑战,特别是影响艾滋病毒感染者 (PWH).
在PWH中使用抗逆转录病毒疗法 (ART) 的流行率不断增加,与肥胖率的加快相吻合.
了解PWH中肥胖的发病因子对于有效的健康管理至关重要.

研究的目的:

审查最近关于PWH体重增加和肥胖风险的文献.
为了检查艾滋病毒疾病进展,心脏代谢疾病和PWH与肥胖的多病症之间的关系.
讨论脂肪组织的变化及其与PWH中代谢并发症的联系.

主要方法:

对观察性和实验性研究的文献综述.
对当代抗逆转录病毒疗法 (ART) 方案的分析,包括整合酶链转移抑制剂 (INSTIs) 和tenofovir alafenamide (TAF).
检查代谢失调,子宫外脂肪沉积和脂肪组织中的免疫细胞变化.

主要成果:

当代ART,特别是INSTIs和TAF,与PWH的体重增加,肥胖和心脏代谢疾病有关,尽管机制尚不清楚.
代谢失调与子宫外脂肪沉积和免疫细胞群体在脂肪组织中的变化有关,在艾滋病毒和肥胖的背景下.
这些因素导致艾滋病毒老龄化人口中代谢性疾病的负担日益增加.

结论:

肥胖越来越多地与PWH中的代谢疾病负担有关.
调查脂肪分区和与HIV/ART相关的脂肪组织功能障碍是关键.
这种理解可以为PWH代谢并发症的预防和治疗策略提供信息.

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