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相关概念视频

Genomics02:02

Genomics

36.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.4K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.9K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.9K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Next-generation Sequencing03:00

Next-generation Sequencing

89.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
89.0K

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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CGG工具包:用于计算基因组学的软件组件.

Dimitrios Vasileiou1, Christos Karapiperis1,2, Ismini Baltsavia3

  • 1Biological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thessalonica, Greece.

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概括
此摘要是机器生成的。

已建立的生物信息学软件用于基因组学研究现在作为开源工具公开提供. 这确保了生命科学研究中关键计算基因组学方法的长期访问和可重复性.

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科学领域:

  • 计算型基因组学计算型基因组学
  • 生物信息学是一种生物信息学.
  • 生命科学 生命科学

背景情况:

  • 公共领域的可用性对于生物信息学软件的长期持久性和可重复性至关重要.
  • 研究软件,特别是广泛使用的方法,经常面临资金不连续性,风险可访问性.
  • 已建立的计算基因组学工具需要重新启动,以确保持续使用和开发.

研究的目的:

  • 重新推出已建立的生物信息学软件组件用于计算基因组学作为开源资源.
  • 确保关键生命科学研究的长期持久性和方法复制性.
  • 为研究提供灵活的基因组比较软件管道.

主要方法:

  • 重新启动旧软件 (1.0.1版本),包括MagicMatch,GeneCAST,CoGenT脚本,GeneRAGE和DifFuse.这些脚本可以重新启动.
  • 将这些工具作为开源在线提供.
  • 提供基本使用和图像表示的文档和示例.

主要成果:

  • 一套已建立的生物信息学工具用于序列匹配,掩盖,搜索,聚类和可视化,现在已公开提供.
  • 重新推出的软件支持在基因组规模上发现蛋白质家族,注释和功能表征.
  • 该工具包作为一个灵活的基因组比较软件管道.

结论:

  • 这些生物信息学工具的开源重新推出确保了它们在计算基因组学中的持续可访问性和使用.
  • 该倡议支持生命科学领域的方法复制性和长期研究.
  • 提供的工具包有助于基因组规模分析和蛋白质家族发现.