结肠直肠癌患者循环长非编码RNA的预后值:一个元分析
Bin Hu1, Yanfei Zhang1, Bingjing Jiang1
1Department of Pathology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua City, Zhejiang Province, China.
Expert review of anticancer therapy
|November 7, 2023
概括
循环中的长非编码RNAs (lncRNAs) 在结直肠癌 (CRC) 中显示出预后潜力. 增加的lncRNAs与较短的整体存活期 (OS) 相关联,而减少的lncRNAs表明更长的OS和改善的无病存活期 (DFS).
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物 生物标志物
背景情况:
- 结肠直肠癌 (CRC) 仍然是一个重大的全球健康挑战.
- 确定可靠的预后生物标志物对于改善患者的治疗结果至关重要.
- 长非编码RNAs (lncRNAs) 正在成为各种癌症中的潜在生物标志物.
研究的目的:
- 评估在结直肠癌 (CRC) 中循环长非编码RNA (lncRNAs) 的预后意义.
- 综合现有关于循环lncRNAs和CRC患者预后之间的关联的证据.
主要方法:
- 对2022年7月之前发表的研究进行了系统的元分析.
- 包括的研究通过全面的数据库搜索来确定 (Embase,科学网,PubMed,柯克兰图书馆).
- 使用纽卡斯尔-太华量表 (NOS) 评估研究质量,使用审查经理5.4和Statata 17.0.0进行统计分析.
主要成果:
- 分析了10篇文章,涉及1473名CRC患者和18个不同的循环lncRNAs.
- 在CRC患者中,13个循环lncRNA被发现是上调的,而5个是下调的.
- 升调的lncRNA与较短的整体存活 (OS) 相关,而降调的lncRNA与较长的OS和改善的无病存活 (DFS) 相关.
- 循环中的lncRNA水平也与TNM阶段,瘤位置和淋巴结转移相关.
结论:
- 循环中的 lncRNAs 显示出相当有前途的结直肠癌预后标记物.
- 进一步的研究是必要的,以验证这些发现,并探索他们的临床实用性.
- 这些非编码RNA可能为CRC的风险分层和治疗监测提供新的途径.
更多相关视频
08:49Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
Published on: May 27, 2016
11.2K
10:35A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
Published on: April 5, 2018
10.4K
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
03:18Non-LTR Retrotransposons
11.5K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K