美国-墨西哥边境沿线狗的Trypanosoma cruzi感染:R0变化与载体物种组成的变化
Luis Fernando Chaves1, Alyssa C Meyers2, Carolyn L Hodo3
1Department of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington IN 47405, USA.
Epidemics
|November 7, 2023
概括
美国政府犬的查加斯病 (Trypanosoma cruzi) 感染在德克萨斯州和新墨西哥州流行,但在亚利桑那州和加利福尼亚州并不流行. 感染动态因地区而异,可能是由于不同的吻虫载体和Trypanosoma cruzi菌株.
科学领域:
- 兽医流行病学 兽医流行病学
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 导致查加斯病的Trypanosoma cruzi感染在美墨边境沿线的美国政府工作犬中很普遍.
- 多样化的生态系统和各种三原子物种 (接吻虫) 居住在这个地区,作为主要载体.
研究的目的:
- 为了调查Trypanosoma cruzi感染狗的动态是否在美墨边境地区有所不同.
- 探索感染模式,载体物种及其载体能力之间的潜在联系.
主要方法:
- 利用可逆催化模型来分析狗的感染动态.
- 估计了基本的繁殖数 (R0) 以评估疾病传播.
- 分析了不同州与狗年龄相关的血清阳性趋势.
主要成果:
- 德克萨斯州 (TX) 和新墨西哥州 (NM) 的R0估计为1.192 ± 0.084,表明本土的建立.
- 在来自亚利桑那州 (AZ) 和加利福尼亚州 (CA) 的狗中,随着年龄的增长,血清阳性降至零.
- 与AZ和CA相比,TX和NM的感染力更高.
结论:
- 狗在西德克萨斯州很可能被感染,感染力足以维持特有查加斯病在德克萨斯州和南德克萨斯州.
- 在AZ和CA中感染力较低的原因可能是不同的载体群落,载体容量或Trypanosoma cruzi血统.
- 在T. cruzi感染动态的区域变化受到载体生态和寄生虫因素的影响.
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