在治疗重度抑郁症和预防复发的自杀念头后进行认知行为疗法:CBT-ENDURE随机临床试验研究协议
Brandon M Kitay1, Eva Murphy2, Matthew Macaluso3
1Department of Psychiatry, Emory University School of Medicine, United States.
Psychiatry research
|November 7, 2023
概括
认知行为疗法 (CBT) 可能有助于预防患有严重抑郁症和自杀念头的患者在治疗后复发. 该CBT-ENDURE试验调查了CBT的CBT.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 埃斯凯特胺适用于具有自杀念头 (MDSI) 的严重抑郁症,但在停止治疗后复发是常见的.
- 自杀的高风险在住院后仍然存在,需要有效的复发预防策略.
- 认知行为疗法 (CBT) 是一种经过验证的方法,用于预防高风险个体的复发和自杀企图.
研究的目的:
- 描述CBT-ENDURE试验的协议,评估CBT在治疗esketamine后预防MDSI患者复发的有效性.
- 评估招募和留住患者参加本试验的可行性.
- 为了确定CBT对回复率的影响,在患者中回应esketamine.
主要方法:
- 该CBT-ENDURE试验将招募100名患有抑郁症和临床显著的自杀念头的患者.
- 所有参与者将在四周内每周两次接受埃斯基他.
- 患者将被随机分配,接受16周的CBT加通常治疗 (TAU) 或单独TAU,并进行6个月的随访期.
主要成果:
- 主要结果是可行性,通过招聘和保留率来衡量.
- 关键的次要结局是患者中复发率,在服用胺二周后显示出显著的益处.
- 该研究由NIMH资助,用于对高风险自杀人口进行安全性和可行性试验.
结论:
- 该CBT-ENDURE试验协议旨在解决对MDSI治疗后长期复发预防策略的关键需求.
- 研究结果将为保持缓解和降低这一脆弱人群中自杀风险的最佳治疗方法提供信息.
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