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相关概念视频

Tight Junctions01:29

Tight Junctions

5.3K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

25.6K
The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Gap Junctions01:37

Gap Junctions

53.0K
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
53.0K
Contact-dependent Signaling01:19

Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
44.7K
Adherens Junctions01:24

Adherens Junctions

4.8K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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相关实验视频

Updated: Jul 11, 2025

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique
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Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique

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紧密的结口是紧密的结口.

Maria S Balda1, Karl Matter1

  • 1UCL Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK.

Current biology : CB
|November 7, 2023
PubMed
概括
此摘要是机器生成的。

细胞屏障,就像血脑屏障一样,维持身体的功能. 紧接点 (TJs) 是形成和调节这些必要的扩散障碍和细胞行为的关键.

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相关实验视频

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科学领域:

  • 细胞生物学 细胞生物学
  • 生理学 生理学 生理学
  • 生物化学 生物化学

背景情况:

  • 半透的细胞扩散障碍对生理功能至关重要,保持不同的内部隔间.
  • 表皮和内皮细胞形成这些屏障,依赖细胞间连接来保持完整性.
  • 这些屏障的破坏会导致各种病理,包括胀和腹.

研究的目的:

  • 阐明紧接口 (TJs) 的结构,组装和屏障功能.
  • 探索粘附结 (AJs) 和焦点粘附在屏障调节中的作用.
  • 讨论细胞极性,基因表达和细胞行为中的其他TJ功能.

主要方法:

  • 审查现有的关于紧密结合,粘附结合和焦点粘附的文献.
  • 在屏障形成中分析细胞间接口的结构和功能作用.
  • 讨论TJ参与细胞表面极性和基因调节.

主要成果:

  • 紧接点 (TJ) 对于创建和维护细胞扩散屏障至关重要.
  • 粘附结 (AJs) 和焦点粘附在调节屏障功能的过程中起着至关重要的作用.
  • TJs还影响细胞极性,基因表达和整体细胞行为.

结论:

  • 紧密的结点对于生理障碍功能和细胞平衡至关重要.
  • 了解TJ结构和功能对于解决与屏障有关的病理至关重要.
  • TJs具有多方面的作用,超越了屏障形成到细胞调节的范围.