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莱普丁受体多态和多囊性卵巢综合征风险之间的关联:基于11项研究的元分析

Na-Na Wang¹, Min Tang¹, Han-Yu Zhang¹

¹Department of Clinical Nutrition, Taihe Hospital, Hubei University of Medicine, Shiyan, P. R. China.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

|November 7, 2023

概括

莱普受体 (LEPR) 基因变异可能会影响患有多囊性卵巢综合征 (PCOS) 的风险. 这项元分析在亚洲人群中发现了显著的关联,这表明LEPR多态性和PCOS易感性之间存在潜在联系.

科学领域:

遗传学遗传学是一个
内分泌学在内分泌学.
生殖医学生殖医学

背景情况:

多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病.
莱普受体 (LEPR) 基因多态性已与PCOS风险有关.
之前的研究显示了关于LEPR多态和PCOS的不一致或有争议的发现.

研究的目的:

进行元分析以澄清LEPR基因多态和PCOS风险之间的关联.
为了更精确地了解LEPR对PCOS的遗传贡献.

主要方法:

在2023年3月1日之前,对五个数据库进行系统的文献搜索.
使用几率比率 (OR) 和95%置信区间 (CI) 的11个出版物的元分析.
在二级RNA结构和LEPR位点的变异效应的in silico分析.

主要成果:

聚合分析显示rs1137101 A/G多态化与一般人群中PCOS风险之间没有显著的关联.
在亚洲人群中观察到rs1137101 A/G的显著关联 (例如,AG与AA:OR=0.51,95%CI=0.32-0.81).
对于rs1805096多态与PCOS风险,也发现了类似的积极关联.

结论:

利普尔基因多态可能与PCOS易感性有关.
研究结果表明,LEPR在PCOS病原体中的潜在作用,特别是在亚洲人群中.
由于样本规模有限,需要进行更多精心设计的,涉及不同族群的研究来证实这些结果.

关键词:

勒普丁受体的受体是什么?多囊性卵巢综合征多囊性卵巢综合征多形态主义的多态主义.易感性易感性易感性

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