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在神经病痛期间,Synaptamide调节脊髓中的质和神经递质活性
Anna Starinets1, Arina Ponomarenko1, Anna Tyrtyshnaia1
1A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia.
Journal of chemical neuroanatomy
|November 7, 2023
概括
氨胺是一种内源性脂肪酸,可降低脊髓质活动和炎症. 这表明它有潜力通过调节神经炎症和促进恢复来治疗外围神经损伤.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 赛纳胺 (N-docosahexaenoylethanolamine) 是一种具有已知的synaptogenic和neurogenic特性的docosahexaenoic酸代谢物.
- 之前的研究表明,Synaptamide在减轻神经病痛,促进复髓化和减少大鼠坐骨神经损伤后的神经炎症方面具有有效性.
研究的目的:
- 为了研究每日施用synaptamide对脊髓活性,细胞因子概况和脊髓内源性大麻素水平在周围神经损伤后的影响.
- 为了评估synaptamide在体外对巨细胞炎症反应的影响.
主要方法:
- 脊髓神经患有慢性收缩损伤 (CCI) 的老鼠在手术后的14天内每天接受synaptamide (4 mg/kg/day).
- 在腰椎脊髓中评估了微质和星质活动.
- 血清和脊髓细胞因子水平 (IL1β,IL6,IL4,IL10) 被调节.
- 在脊髓中测量了合成胺和胺度.
- 用LPS刺激巨细胞培养,以评估synaptamide对炎症标志物的作用.
主要成果:
- 施用赛纳普胺降低了脊髓中的微和星质活动.
- 它调节了血清和脊髓组织中的促炎和抗炎细胞因子水平.
- 胺治疗增加了脊髓中的内源性胺和胺度.
- 在体外,synaptamide在LPS诱导的炎症性巨细胞培养中增强了IL10,CD206和N-乙乙醇胺-化酸胺酶合成.
结论:
- 在外围神经受伤后,Synaptamide有效调节脊髓中的质激活和细胞因子表达.
- 这些发现凸显了synaptamide在控制神经炎症和促进神经损伤后恢复方面的潜在治疗作用.
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