原发性乳腺癌检测方法和无病间隔,调整以领先时间为准
Linda de Munck1, Anouk H Eijkelboom1,2, Johannes D M Otten3
1Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.
Journal of the National Cancer Institute
|November 7, 2023
概括
与临床检测或非查相关的癌症相比,通过查检测的乳腺癌显示出改善的无疾病间隔. 这一发现甚至在考虑选研究中领先时间偏差后也是如此.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 对查检测到的乳腺癌对无病区间的影响的理解有限.
- 由于未经调整的领先时间偏差,可能高估了查效益.
研究的目的:
- 研究乳腺癌检测方法与无病间隔之间的关联.
- 在对查有效性的分析中考虑头时间偏差.
主要方法:
- 对2005-2008年荷兰癌症登记数据的分析 (50-76岁女性).
- 查检测和临床检测癌症的比较 (2005年队列,10年随访).
- 查检测,间隔和非查相关癌症的比较 (2006-2008年队列,5年随访).
- 应用一个领先时间调整方法和分析纠正混变量.
主要成果:
- 在2005年队列中,查检测到的癌症与改善的无病间隔相关 (HR=0.77,95% CI=0.68-0.87).
- 查检测 (HR=0.76,95% CI=0.66-0.88) 和间隔癌症 (HR=0.88,95% CI=0.78-0.99) 在2006-2008年队列中显示出无疾病间隔的改善.
- 在对混变量进行校正后,关联仍然保持一致,而不是领先时间.
结论:
- 与临床检测或非查相关的癌症相比,通过查检测的乳腺癌显示出更好的无疾病间隔.
- 即使在调整引时间后,改善的结果也很明显,支持查的好处.
更多相关视频
11:47Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
Published on: February 8, 2013
11.9K
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
296
相关概念视频
Cancer Survival Analysis
357
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
357
Kaplan-Meier Approach
154
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
154
Introduction To Survival Analysis
250
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
250
