[用于诊断小肠细菌生长的单一甲呼吸试验]
1Department of Gastroenterology,General Hospital,Tianjin Medical University,Tianjin 300052,China.
Zhonghua nei ke za zhi
|November 7, 2023
概括
单次甲呼吸试验 (SHMBT) 显示出诊断小肠细菌过度生长 (SIBO) 的前景. 在呼出的气息中测量甲 (CH4) 和 (H2) 可以有效地识别SIBO,合并的CH4和H2提供更高的准确性.
科学领域:
- 胃肠病学 胃肠病学
- 诊断医学 诊断医学 诊断医学
- 微生物学 微生物学
背景情况:
- 小肠细菌过度生长 (SIBO) 是一种小肠细菌过度生长的情况.
- 准确诊断SIBO对于有效治疗和管理胃肠道症状至关重要.
研究的目的:
- 评估单次甲呼吸试验 (SHMBT) 的诊断准确性,以确定SIBO.
- 为了确定用于SIBO诊断的呼气中甲 (CH4) 和 (H2) 的最佳切断值.
主要方法:
- 一项涉及162名胃肠道症状患者和69名健康对照者的横截面研究.
- 进行了SHMBT,并使用接收器操作特征 (ROC) 曲线分析了结果.
- 一组验证组的2655名患者被用于确认诊断性能.
主要成果:
- 与对照组相比,患有胃肠道症状的患者的SHMBT阳性率明显高 (35.2%对21.7%).
- 在患者组中,甲 (CH4) 含量显著更高.
- 结合的CH4和H2测量显示出SIBO诊断的高特异性 (85.0%) 和准确性 (71.7%).
结论:
- 单次甲呼吸试验 (SHMBT) 是诊断SIBO的一种可行的方法.
- 使用特定的结合CH4和H2的切断值 (禁食CH4≥5ppm,或CH4≥4ppm和H2≥24ppm) 似乎是SIBO检测的可行和准确的.
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