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Updated: Jul 11, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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在淋巴瘤中通过突变的IRF4进行转录重编程

Nikolai Schleussner1,2,3, Pierre Cauchy4,5,6,7, Vedran Franke8

  • 1Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Biology of Malignant Lymphomas, 13125, Berlin, Germany.

Nature communications
|November 7, 2023
PubMed
概括

干扰素调节因子4 (IRF4) 的特定突变改变了它在淋巴瘤中的DNA结合. 这种IRF4突变导致基因调节的切换,影响B细胞身份和疾病进展.

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