高增殖率和低ER相关信号的乳腺癌的预后不好,具有独特的分子特征,对治疗有影响
Luca Licata1,2, Marco Barreca3, Barbara Galbardi1,2
1Department of Medical Oncology, San Raffaele Hospital, Milan, Italy.
British journal of cancer
|November 7, 2023
概括
高增殖,低ER信号乳腺癌 (MKS/ERS) 显示预后不佳. 免疫疗法与新辅助化疗相结合可能会改善这些侵袭性瘤的结果.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 高增殖 (MKShi) 和低雌激素受体信号 (ERSlo>) 的光线性乳腺癌的预后不佳.
- 这些侵袭性瘤对当前的治疗策略提出了独特的挑战.
研究的目的:
- 研究MKS/ERS乳腺瘤的治疗反应和分子特征.
- 为这个预后不佳的子组确定潜在的治疗策略.
主要方法:
- 来自接受新辅助化疗 (NAC) 治疗的患者的基因表达数据的分析,有或没有 pembrolizumab,和内分泌治疗 (NET) 有或没有palbociclib.
- 使用TCGA数据评估palbociclib耐药性和免疫治疗反应的突变格局和生物标志物.
主要成果:
- 与MKShi/ERSlo瘤相比,MKShi/ERSlo瘤对NAC的病理反应率较高,但复发风险增加.
- 这些瘤经常含有TP53和PIK3CA突变,生物标志物表明对内分泌疗法和palbociclib的耐药性.
- 添加到NAC的 pembrolizumab 改善了MKShi/ERSlo瘤的病理完整响应率.
结论:
- MKShi/ERSlo瘤对化疗敏感,但对内分泌疗法和palbociclib有抗性,与悲惨的结果相关.
- 生物标志物分析和临床数据表明,免疫疗法在这种乳腺癌亚组中具有潜在的治疗作用.
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