增加非白虫Candida趋势对免疫功能低下患者诊断的影响
Rasha M Abdel-Hamid1, Hadir A El-Mahallawy2, Nesma E Abdelfattah2
1Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt. rasha.elgyar@nci.cu.edu.eg.
概括
非白虫Candida物种越来越多地在癌症患者中引起侵入性白病. 目前的PCR方法只针对五种常见物种,但错过了罕见物种,因此需要更广泛的识别技术来有效管理患者.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 侵袭性角膜病 (IC) 是一个日益严重的全球健康问题,其标志着非白虫Candida (NAC) 种类的增加.
- 癌症患者特别容易感染IC,各种Candida物种有助于感染.
研究的目的:
- 评估半嵌套PCR (sn-PCR) 针对五种流行Candida物种的充分性,用于识别癌症患者的病原体.
- 评估血液学和固体瘤癌症患者中Candida感染的流行病学趋势.
主要方法:
- 在一年内从癌症患者中收集了Candida分离物.
- 使用染色体和多重sn-PCR与Candida albicans,C. tropicalis,C. glabrata,C. krusei和C. parapsilosis复合物的原料进行了物种鉴定.
主要成果:
- 在Candida感染中,NAC物种占大多数 (70.5%).
- 很大一部分 (13.3%) 的罕见的Candida物种没有被向性sn-PCR识别出来,超过一半的癌症患者导致了候选血症.
- 最近的手术,化疗,长时间住院和生殖尿路癌症被确定为 кандидоз的重要危险因素.
结论:
- 仅针对五种最常见的Candida物种的sn-PCR方法不足以对癌症患者进行全面的诊断.
- 更广泛的频谱识别技术对于准确诊断和在这个脆弱人群中对侵入性真菌感染的最佳管理至关重要.
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