遗传维生素和败血症风险的因果关系:一个双样本的门德尔随机化研究
Chen Lou1, Zhizhen Meng2, Yiyi Shi3
1School of The First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, 325000, China.
BMC infectious diseases
|November 7, 2023
概括
这项孟德尔的随机化研究没有发现遗传证据将叶酸,B12,C,D或K等维生素与败血症风险联系起来. 需要进一步的试验来证实这些关于维生素影响的发现.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 传染病研究 传染病研究
背景情况:
- 对维生素和败血症的观察研究产生了不一致的结果.
- 调查维生素摄入量和败血症之间的因果关系至关重要.
- 门德尔随机化 (MR) 提供了一种评估因果关系的遗传方法.
研究的目的:
- 为了评估各种维生素对败血症风险的因果关系,使用孟德尔的随机设计.
- 为了利用遗传变异作为不同维生素的工具变量.
主要方法:
- 采用孟德尔随机化 (MR) 研究,遵循STROBE-MR指南.
- 利用了叶酸,维生素B12,B6,A,C,D和K的遗传仪器变量.
- 分析了五种败血症严重程度,选了混因素,并应用了多种MR方法 (MR-egger,IVW-RE,IVW-FE,沃尔德比率).
主要成果:
- 在研究的维生素和败血症风险之间没有发现统计学上显著的因果关系.
- 所有测试的维生素 (叶酸,B6,B12,A,D,K,C) 的几率比率表明对败血症没有显著影响.
- 跨不同败血症严重程度的子组分析证实了没有显著的关联.
结论:
- 这项MR研究没有为维生素和败血症之间的因果关系提供遗传证据.
- 这些发现表明,对维生素水平的遗传倾向不会影响败血症风险.
- 建议进行进一步的随机对照试验,以确定维生素在败血症中的作用.
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