子宫内膜异位症和试管婴儿治疗结果:解开过程过程
Edgardo Somigliana1,2, Letizia Li Piani3, Alessio Paffoni4
1Academic Center for Research on Adenomyosis and Endometriosis, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Reproductive biology and endocrinology : RB&E
|November 8, 2023
概括
晚期子宫内膜异位症对试管婴儿的成功影响很小,除了对卵巢储量的外科手术影响. 卵巢反应,卵细胞质量和胚胎发育在很大程度上不受影响,这表明子宫内膜异位症本身对试管婴儿结果的影响很小.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 子宫内膜异位症研究研究
背景情况:
- 晚期子宫内膜异位症与减少体外受精 (IVF) 成功率有关.
- 手术切除子宫内膜瘤可能会损害卵巢储备,导致IVF结果下降.
- 其他潜在的机制包括受损的卵巢刺激,卵细胞质量,受精,胚胎发育和植入.
研究的目的:
- 系统地审查有关子宫内膜异位症妇女体外受精过程不同阶段的文献.
- 评估子宫内膜异位症对卵巢反应,卵细胞和胚胎质量以及子宫内膜接受性的影响.
- 区分子宫内膜异位症与外科手术对试管婴儿成功的影响.
主要方法:
- 文学搜索侧重于对子宫内膜异位症患者进行试管婴儿的研究.
- 在患有单侧子宫内膜瘤的妇女中,优先进行患者内卵巢反应比较.
- 包括研究,精心匹配控制的混因素.
主要成果:
- 子宫内膜异位症对卵巢反应的影响微不足道,仅在子宫内膜异位瘤>4厘米的情况下略有减少;卵泡类固醇生成不受影响.
- 卵细胞质量,受精率和胚胎发育没有受到损害;细胞内精子注射 (ICSI) 不适用,形积分率没有增加.
- 子宫内膜受容性不受到子宫内膜异位症的影响或仅受到微小的影响.
结论:
- 除了对卵巢储备的手术损伤外,子宫内膜异位症不会显著影响试管婴儿的结果.
- 卵巢反应,卵细胞质量和胚胎发育在患有子宫内膜异位症的女性中基本保持不变.
- 子宫内膜受容性受到最小的影响,这表明子宫内膜异位症本身对试管婴儿成功的影响有限.
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