相关实验视频

Updated: Jul 11, 2025

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

网关反射描述了新的神经免疫通讯,在特定的血管中建立免疫细胞网关

Hiroki Tanaka¹, Rie Hasebe^2,3, Kaoru Murakami²

¹Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-Ku, Sapporo, 060-0815, Japan. htanaka@igm.hokudai.ac.jp.

Bioelectronic medicine

|November 8, 2023

概括

网关反射允许免疫细胞进入中枢神经系统,导致神经炎症. 操纵神经通道可以通过打开或关闭这些通道来控制自身免疫性疾病.

科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
病理学病理学病理学

背景情况:

神经炎症涉及到中枢神经系统中免疫和神经元细胞之间的复杂相互作用.
神经元和免疫系统之间的双向通信调节免疫和炎症过程.
网关反射描述了免疫细胞透到中枢神经系统,绕过血脑屏障.

研究的目的:

描述道反射的发现和调节.
调查网关反射在自身免疫性疾病发展中的作用.
探索神经通路操纵控制自身免疫性疾病的潜力.

主要方法:

使用小鼠模型进行实验性自身免疫性脑膜炎,全身性红斑狼,实验性自身免疫性脑膜炎和炎症性关节炎.
在各种疾病模型中确定了特定的血管位置,作为免疫细胞透的门户.
研究了环境刺激对神经通路的影响,通过道反射影响免疫反应.

主要成果:

在小鼠模型中发现了网关反射的多种模式.
在大脑,脊髓,视网膜和脚关节的特定血管中证明了网关的形成.
表明环境刺激激活神经通路,通过道反射调节免疫反应,影响自身免疫性疾病的进展.

结论:

网关反射是神经炎症和自身免疫性疾病发展的关键机制.
人工操纵神经通路提供了一种潜在的策略,通过调节网关访问来控制自身免疫性疾病.

关键词:

血液-大脑屏障是什么?这是一个IL-6放大器.免疫调节免疫调节炎症炎症是一种炎症.神经免疫系统之间的沟通.

更多相关视频

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier

Published on: April 5, 2017

相关概念视频

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

Overview of Cell-Matrix Interactions

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...