有条件与无条件的激励措施,以最大限度地回报参与者在临床试验中填写的问卷:在试验中的一个集群随机化研究
Johanna Cook1, Jonathan A Cook2, Emily Bongard3
1The Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. johanna.cook@phc.ox.ac.uk.
Trials
|November 8, 2023
概括
对临床试验参与者的货币激励没有显示出问卷回报率的显著差异,无论是提前提供还是完成后提供. 有条件的激励措施更具成本效益.
科学领域:
- 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
- 激励研究 激励研究
背景情况:
- 参与者保留对于临床试验有效性至关重要.
- 货币激励措施可能会提高保留率,但最佳时机和条件尚不清楚.
研究的目的:
- 基于激励条件的后续问卷的回报率进行比较.
- 调查提供前期 (无条件) 和每日回报 (有条件) 的货币激励是否会影响参与者的参与.
主要方法:
- 在ALIC4E研究中进行集群随机试验,比较无条件和有条件的货币券激励措施.
- 匹配的GP实践被随机选择;主要结果是返回的14天日常日记的比例.
- 线性回归分析根据地点对进行调整,对返回时间和成本等结果进行敏感性分析.
主要成果:
- 在无条件 (0.58) 和有条件 (0.73) 激励组之间,每日回报比例没有统计学上显著的差异.
- 敏感性分析没有显示出明显的差异,尽管有些人建议有条件激励措施的潜在好处.
- 有条件的激励措施更具成本效益,每份返回的日记节省了大约23英.
结论:
- 没有明确的证据支持基于激励条件的问卷回报率存在显著差异.
- 返回时间和日记的完整性在不同组中是相似的.
- 有条件的激励措施在临床试验保留策略中提供了潜在的成本节约优势.
更多相关视频
00:04A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
10.7K
07:31A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
Published on: February 13, 2020
7.0K
相关概念视频
Clinical Trials
6.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.8K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
133
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
133
Blinding
2.5K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.5K
Cochran's Q Test
360
Cochran's Q Test is a nonparametric statistical test used to determine if there are potential differences in the outcomes of three or more related groups on a binary (yes/no) or dichotomous outcome. It is essentially an extension of the McNemar Test, which is limited to two related samples - Cochran's Q test can handle three or more related samples, making it more versatile in scenarios where subjects are measured under multiple conditions. The test statistic follows a Chi-Square...
360
Group Design
8.9K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
8.9K
Surveys
14.8K
Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
14.8K
