治疗COVID-19后病情的伏尔托克塞丁:一项随机对照试验
Roger S McIntyre1,2,3, Lee Phan3, Angela T H Kwan3,4
1Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.
Brain : a journal of neurology
|November 8, 2023
概括
西可以改善COVID-19后患者的抑郁症状和生活质量. 虽然最初没有表现出认知益处,但当调整为C反应蛋白 (CRP) 水平时,西显示出亲认知效应.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 后COVID-19状态 (PCC) 呈现出显著的认知缺陷,情绪障碍和与健康相关的生活质量 (HRQoL) 的降低.
- 目前没有批准的治疗药物用于治疗PCC症状.
- 伏尔托克塞丁是一种抗抑郁药,可能对认知功能产生影响.
研究的目的:
- 评估沃尔提奥塞丁在改善PCC患者认知功能,抑郁症状和HRQoL方面的疗效.
- 调查基线C反应蛋白 (CRP) 作为认知效应调节者的作用.
主要方法:
- 一项为期8周的随机,双盲,安慰剂对照研究,涉及149名患有世卫组织定义的PCC的成年人.
- 参与者每天接受西 (5-20毫克) 或安慰剂.
- 主要结局:数字符号替换测试 (DSST) 得分的变化. 二级结局:抑郁症状的变化 (QIDS-16) 和HRQoL (WHO-5幸福度表).
主要成果:
- 在未经调整的模型中,西没有显著改善整体认知功能 (P = 0.361).
- 在调整基线CRP (P = 0.012) 时,观察到有利于西的显著的治疗 × 时间相互作用.
- 与安慰剂相比,Vortioxetine显著改善了与基线CRP高于平均值 (P = 0.045),抑郁症状 (P < 0.001) 和HRQoL (P < 0.001) 的参与者的DSST得分.
结论:
- 在PCC患者中,沃尔托克塞丁显示出显著的抗抑郁药和HRQoL改善作用.
- 当对基线CRP水平进行调整时,观察到vortioxetine的益智效应,这表明CRP是潜在的调节者.
- 进一步的研究是有必要的,以探索子在管理PCC的认知和情绪症状中的作用.
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