阿根廷活跃狼:多中心和国家注册表的结果
Rosana M Quintana1, Mercedes García2, Lucila Garcia2
1Grupo Oroño, Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina.
Lupus
|November 8, 2023
概括
主动性系统性红斑狼 (SLE) 疾病在阿根廷患者中很常见,与较短的诊断时间和较差的结果,如住院和器官损伤有关. 年轻的年龄与活跃的疾病有关.
科学领域:
- 类风湿病学 类风湿病学
- 系统性红斑狼研究研究
- 临床流行病学临床流行病学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,其临床表现和疾病活性各不相同.
- 了解与活跃疾病相关的因素对于改善患者治疗结果和治疗策略至关重要.
研究的目的:
- 在阿根廷的SLE注册中调查患者特征与疾病活动之间的关系.
- 为了确定南美狼队伍中活跃疾病的预测因素.
主要方法:
- 采用了横截面研究设计.
- 使用既定标准对疾病活动进行分类:缓解治疗后,低疾病活动-多伦多队列 (LDA-TC),改性狼低疾病活动 (mLLDAS) 和活跃疾病.
- 用描述性分析和逻辑回归来分析1346名患者的数据.
主要成果:
- 大多数患者 (85.4%) 呈现活跃疾病.
- 活跃疾病与年龄较小,诊断时间较短和住院率较高显著相关.
- 多变量分析确定肺炎,持续的蛋白尿,炎和住院是活跃疾病的关键预测因素,而年龄较大是保护性的.
结论:
- 在这个阿根廷队列中,活跃的SLE是普遍存在的,并且与延迟诊断和不良结果有很强的相关性.
- 脏,神经和血清干扰是活跃疾病的重要指标.
- 这些发现强调了早期诊断和积极管理的必要性,以减轻SLE患者的长期发病率.
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