新型pH响应性氨基酸衍生物的合成和表征,用于组织工程和药物输送的基
Shokouh Khodayar1, Mohammad Reza Shushizadeh1,2, Elham Tahanpesar1
1Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.
Current organic synthesis
|November 8, 2023
概括
新的pH敏感的甲基酸盐 (SA) 水凝是使用胺合成的. 这些先进的水凝在更高的pH值下表现出增强的胀,使它们成为控制药物输送应用的理想选择.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 水凝具有可生物降解性,生物相容性和刺激反应性,这对于生物医学应用至关重要.
- 对刺激敏感的聚合物,特别是对pH敏感的聚合物,由于它们对生理变化的反应,对于控制药物释放至关重要.
- 在水凝中控制胀可以调节药物扩散的时间和空间,提高治疗效果并减少副作用.
研究的目的:
- 合成具有增强凝强度和pH敏感度的新型藻酸盐 (SA) 衍生物,用于药物输送.
- 调查碳化合物链长度对基于SA的水凝特性的影响.
- 开发环境敏感的水凝,以提高生物医学应用中的性能.
主要方法:
- 通过胺键连接将短链[1,3-胺 (DAP) ]和长链[1,7-胺 (DAH) ]碳化合物移植到藻酸盐 (SA) 上.
- 使用FTIR,1HNMR,XRD,元素分析 (CHNS) 和热分析 (TGA,DTA,DSC) 进行合成的移植共聚合物的表征.
- 使用环境扫描电子显微镜 (ESEM) 对水凝表面形态的研究和在不同温度和pH条件下的性能评估.
主要成果:
- 随着碳化合物链长度 (DAP) 的缩短,水凝强度和交叉连接增加.
- 酸衍生物表现出积极的pH敏感性,pH值7.4时与pH值4.4时相比,增强胀.
- 合成的水凝显示出有利的机械性能和胀比率,适合于伤口包裹应用.
结论:
- 通过胺键连接成功合成了pH敏感的DAP-g-SA和DAH-g-SA基.
- 这些新型的SA衍生物在高pH (7.4) 时显著增强胀,在低pH (4.4) 时减少胀.
- 响应pH的水凝对于控制药物输送系统,如胰岛素输送,是有前途的,因为它们具有可调节的膨胀,生物降解性和生物相容性.
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