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多发性硬化和神经炎症中的星:隙通路的作用是什么?
Pierre Mora1, Candice Chapouly1
1Université de Bordeaux, Institut national de la santé et de la recherche médicale (INSERM), Biology of Cardiovascular Diseases, Pessac, France.
Frontiers in immunology
|November 8, 2023
概括
多发性硬化症 (MS) 是一种神经退行性疾病,影响着数百万人. 这篇综述探讨了星病,并强调了NOTCH信号作为MS神经炎症的关键调节器.
科学领域:
- 神经免疫学 神经免疫学
- 中枢神经系统疾病 中枢神经系统疾病
- 天星细胞生物学 天星细胞生物学
背景情况:
- 多发性硬化症 (MS) 是中枢神经系统 (CNS) 的慢性自身免疫性炎症性疾病,影响全球超过230万人,主要是50岁以下的人.
- 目前对多发性硬化症的治疗方法,主要是免疫疗法,有效性有限,并带有显著的副作用,强调需要新的治疗点.
- 多发性硬化症的早期发病包括血脑屏障 (BBB) 的破坏,导致,兴奋毒性和中枢神经系统炎症,而星球细胞在神经血管单元中发挥着至关重要的作用.
研究的目的:
- 在神经炎症的背景下审查目前对星病的理解.
- 突出NOTCH信号在调节神经炎症期间的天体细胞反应性的中心作用,特别是在多发性硬化症中.
- 讨论星病机制的重要性,尽管它们在调节多发性硬化症患者自身免疫反应方面的重要性仍然未得到充分研究.
主要方法:
- 文献综述综合了关于星病和神经炎症的当前知识.
- 对天体细胞活性在多发性硬化症进展中的作用的分析.
- 使用人类和实验模型检查证据,证明NOTCH信号在星病中存在.
主要成果:
- 星病,以星细胞的形态和分子变化为特征,驱动MS中从急性炎症性损伤过渡到慢性神经退行.
- NOTCH信号被确定为天体细胞反应的关键调节器,这是天体细胞分裂的核心过程.
- 现有的反应性星球细胞标记物的综合命名法不包括NOTCH信号,这表明目前的理解存在差距.
结论:
- 星症是多发性硬化症神经炎症级联中的一个关键过程.
- NOTCH1受体成为星病的关键调节器,为MS提供了潜在的治疗标.
- 进一步探索星病中NOTCH信号的研究是有必要的,以开发用于管理多发性硬化症的新策略.
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