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在固体瘤微环境中通过高度多重化成像镜头划分空间细胞-细胞相互作用

David E Cohn¹, Aisling Forder¹, Erin A Marshall¹

¹Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

Frontiers in immunology

|November 8, 2023

概括

瘤微环境 (TME) 通过复杂的细胞相互作用驱动癌症生长和转移. 新的空间成像和生物分析工具允许对这些相互作用进行详细的研究,以进行个性化癌症治疗.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物信息学是一种生物信息学.

背景情况:

瘤微环境 (TME) 包含多样化的细胞,它们广泛交流,影响瘤生长和转移.
瘤免疫微环境 (TIME) 内的相互作用显著重编程细胞,促进了亲瘤原性表型.
针对特定的TIME相互作用,如PD-1/PD-L1,已经取得了治疗进展.

研究的目的:

在TME中审查促进瘤的非细胞自主相互作用.
调查当前的数字病理学和生物图像分析技术,用于TME评估.
讨论这些技术在研究细胞与细胞相互作用方面的优点和局限性.

主要方法:

关于TME相互作用及其对瘤行为的影响的文献综述.
数字病理技术和生物图像分析程序的调查.
空间数据的分析和多重细胞标志物质询.

主要成果:

常见的TME分析往往缺乏空间数据或询问有限的标记,阻碍了全面的细胞表型.
先进的数字病理学和生物图像分析能够在临床样本中对TME进行高分辨率的多重分析.
在患者之间,TME的空间组织是高度可变的.

结论:

高分辨率的空间成像和分析技术为研究TME非细胞自主相互作用提供了强大的工具.
了解这些相互作用对于描述瘤行为至关重要.
利用这些技术可以为个性化癌症治疗策略提供信息.

关键词:

免疫检查点封锁封锁多重成像多重成像成像非细胞自主相互作用.瘤免疫微环境 (时间)瘤微环境 (TME) 是指瘤的微环境.透到瘤中的淋巴细胞

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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...