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放射性 (131I) 治疗在甲状腺功能过高患者中的结果
Muhammad Sajjad Ali Khan1, Arshad Hussain2, Shahzad Ahmad3
1Muhammad Sajjad Ali Khan, FCPS Medicine. North West Teaching Hospital & Research Center, Peshawar, Pakistan.
Pakistan journal of medical sciences
|November 8, 2023
概括
放射性-131疗法有效治疗甲状腺功能障碍,但剂量选择至关重要. 与较低剂量相比,更高的剂量 (> 20 mCi) 导致了更多的甲状腺功能改善结果和较少的甲状腺功能低下症.
科学领域:
- 内分泌学 在内分泌学.
- 核医学就是核医学.
- 内部医学 内部医学
背景情况:
- 甲状腺功能障碍是一种常见的内分泌疾病.
- 放射性-131疗法 (RIT) 是甲状腺功能障碍症的标准治疗方法.
- 由于结果的变化,RIT的最佳剂量仍然是争论的主题.
研究的目的:
- 为了评估甲状腺结果在高甲状腺患者RIT后六个月.
- 确定影响这些结果的因素,包括放射性 (RAI) 剂量和患者特征.
主要方法:
- 对153名接受RIT治疗的甲状腺过高患者进行了回顾性观察性研究.
- 2013-2019年间从医疗记录中收集的数据.
- 分析基线特征,临床特征,实验室结果和甲状腺成像.
主要成果:
- 在RIT后的6个月内,19.6%的甲状腺功能正常,9.2%的甲状腺功能仍然高,25.5%的甲状腺功能低下.
- 六个月后的缓解率为80.95%.
- 较高的RAI剂量 (> 20mCi) 与较低的剂量 (≤ 20mCi; 83.0% 甲状腺功能低下) 相比,与更多的甲状腺状态 (64.5%) 和较少的甲状腺功能低下 (17%) 相关联.
- 甲状腺功能障碍的病因,而不是性别,在六个月后显著.
结论:
- RIT对甲状腺功能障碍有效,但需要小心剂量定位.
- 较高的RAI剂量似乎可以降低甲状腺功能低下的发病率,并增加甲状腺功能改善的结果.
- 需要进一步的研究来确定精确的剂量指南.
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