人类细胞巨化病毒免疫球蛋白G反应和青少年肺结核:一个病例对照研究
Jeremi Swanepoel1,2, Gert van Zyl3, Anneke C Hesseling1
1Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Open forum infectious diseases
|November 8, 2023
概括
高的人类细胞巨核病毒 (HCMV) IgG标位与青少年肺结核病的几率增加有关. 爱斯坦-巴尔病毒 (EBV) 在本研究人群中没有与结核病风险相关.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 新出现的证据表明,疹病毒,特别是人类细胞巨乳病毒 (HCMV) 和爱斯坦-巴尔病毒 (EBV),可能会影响结核病 (TB) 疾病的进展.
- 处于高结核病负担环境中的青少年特别容易受到这些共同感染的影响.
研究的目的:
- 研究HCMV和EBV血清阳性和免疫球蛋白G (IgG) 标位与青少年肺结核风险之间的关联.
- 为了确定疹病毒感染是否有助于南非青少年群体的结核病发展.
主要方法:
- 在南非开普敦,对50名被诊断患有肺结核的青少年和51名健康的,暴露于结核的青少年 (年龄在10-19岁) 进行了一项无匹配的病例对照研究.
- 血清样本使用自动化酶免疫试验分析了HCMV IgG和EBV核抗原 (EBNA) IgG标位.
- 使用无条件后勤回归来估计疹病毒标位和结核之间的关联的几率比率.
主要成果:
- 所有参与者都表现出HCMV IgG (100%) 和EBV EBNA IgG (95%) 的高血清流行率.
- 与健康对照组相比,患有肺结核的青少年的HCMVIgG标位显著更高 (P = .04).
- 较高的HCMVIgG标位 (上三位) 与肺结核的几率增加3.67倍 (95% CI,1.05-12.84;P = .04),随着标位上升的几率增加的趋势 (P = .04).
- 在EBV EBNA IgG值和结核病风险之间没有发现显著的关联.
结论:
- 在这种高结核病负担环境中的青少年中,HCMV和EBV敏感性的高患病率存在.
- 升高的HCMVIgG标位与青少年肺结核有显著的关联,这表明它可能在疾病发病过程中起作用.
- 需要进一步的研究来阐明将HCMV感染与结核病进展联系在一起的机制.
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