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实施加利福尼亚COVIDNet - 为全州SARS-CoV-2基因组监测开展多部门合作

Debra A Wadford¹, Nikki Baumrind¹, Elizabeth F Baylis¹

¹California Department of Public Health, Richmond, CA, United States.

Frontiers in public health

|November 8, 2023

概括

加利福尼亚COVIDNet建立了一个大规模的SARS-CoV-2基因组监测计划,对近80万个基因组进行了测序. 这一倡议为未来的公共卫生危机提供了一个至关重要的数据框架.

科学领域:

公共卫生公共卫生
基因组监测基因组监测
病毒学病毒学

背景情况:

由于病毒的快速传播和演变,SARS-CoV-2大流行带来了重大的公共卫生挑战.
有效的基因组监测对于监测病毒变异和告知公共卫生反应至关重要.

研究的目的:

在加利福尼亚州建立一个大规模的SARS-CoV-2基因组监测计划.
为了监测SARS-CoV-2变种的传播,检测新兴菌株,并描述疫情.

主要方法:

加利福尼亚SARS-CoV-2全基因组测序 (WGS) 倡议或加利福尼亚COVIDNet成立.
它涉及50个实验室合作伙伴的多部门合作,包括公共卫生,临床和学术设施.
数据管理和计算基础设施是使用传统和基于云的解决方案开发的.

主要成果:

自2021年3月以来,加利福尼亚COVIDNet已经测序了超过45万个SARS-CoV-2基因组.
该计划已经从加利福尼亚州所有61个当地卫生管辖区生成了近80万个基因组.
该州超过5%的阳性测试已经被测序,地理区域的比例一致.

结论:

加利福尼亚COVIDNet通过创新伙伴关系成功克服了实施挑战,创建了一个有价值的基因组监测计划.
该倡议提供了关键数据,以告知加利福尼亚州的COVID-19公共卫生反应.
建立的数据框架和基础设施对于应对未来的公共卫生紧急情况至关重要.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.基于云计算的计算.数据管理数据管理基因组监测对基因组进行监测.整个基因组的测序.

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