发生性关节骨关节炎的风险因素和人口可归因的部分
Jos Runhaar1, Annemaria C van Berkel1, Rintje Agricola2,3
1Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
概括
关节骨关节炎 (OA) 的初级预防至关重要. 低教育程度和超重是老年人部骨关节炎发展的关键可修改的危险因素.
科学领域:
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
- 预防医学 预防医学
背景情况:
- 关节炎 (OA) 对健康构成重大负担.
- 有效的治疗方法有限,初级预防研究还在芽.
- 确定可修改的风险因素对于预防策略至关重要.
研究的目的:
- 为了确定中年和老年人中发生的临床和放射性关节OA的危险因素.
- 评估已识别的风险因素的预防重要性.
- 估计可修改的风险因素的人口归因分数 (PAFs).
主要方法:
- 鹿特丹研究队列 (55岁以上的个人) 的回顾性分析.
- 评估基线因素,包括年龄,性别,BMI,吸烟,教育,糖尿病,CRP和结构异常 (凸轮形态学,乙骨肌力发育不良).
- 评估11年间发生的临床和放射性关节骨关节炎的相关性,计算显著可修改因素的PAF.
主要成果:
- 临床关节OA发生在19.9%的参与者中,而放射性关节OA发生在9.9%的参与者中.
- 与临床部OA相关的因素包括女性性别,低教育程度 (PAF 21.4%) 和放射性部OA (PAF 3.4%).
- 与放射性关节OA相关的因素包括女性的性别,年龄,超重 (PAF 20.0%),凸骨形态 (PAF 7.9%),体形 (PAF 3.6%),和放射性指OA (PAF 4.7%).
结论:
- 低教育水平是临床部OA的一个显著可修改的风险因素.
- 超重是放射性关节OA的一个显著可修改的风险因素.
- 这些发现突出了在老年人群中预防关节骨质炎的关键目标.
更多相关视频
相关概念视频
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Coronary Artery Disease I: Introduction
17
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
17
Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
Bones of the Lower Limb: Femur and Patella
2.5K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
2.5K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Atherosclerosis I: Introduction
9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9


