通过喷雾干燥技术开发 olanzapine 固体分散剂,使用选设计提高溶解度
Leena Patil1, Umakant Verma1, Rahul Rajput1
1University Institute of Chemical Technology, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon-425001, Maharashtra, India.
ADMET & DMPK
|November 8, 2023
概括
这项研究使用喷雾干燥的固体分散增强了 olanzapine (OLZ) 的溶解性. 这种新型配方显著提高了药物的溶解性和溶解率,从而提高了口服生物可用性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 一种精神药物 olanzapine (OLZ) 具有较差的水溶性,限制了其口服生物可用性.
- 增强的溶解性对于改善 olanzapine 在治疗精神分裂症和双相情感障碍等疾病的治疗疗效至关重要.
研究的目的:
- 开发一种口服剂型,增强 olanzapine 的可溶性和溶解率.
- 为了研究喷雾干燥固体分散剂对奥兰扎配方的有效性.
主要方法:
- 使用喷雾干燥技术准备了olanzapine固体分散剂,其中使用了聚乙烯基pyrrolidone K-30,单氨基 glycyrrhizinate pentahydrate 和二氧化.
- 描述包括X射线衍射 (X-RD),差分扫描热度计 (DSC),里埃变换红外光谱,溶解度和封装效率 (EE) 研究.
主要成果:
- X射线衍射证实了在固体分散中的奥兰扎的无形性质.
- 与纯 olanzapine (0.983 mg/ml) 相比,准备好的固体分散物具有显著更高的溶解率 (11.51 mg/ml).
- 封装效率在64%到90%之间.
结论:
- 喷雾干燥的固体分散有效地提高了奥兰zapine的可溶性和溶解率.
- 该配方有可能改善口服生物利用率和治疗结果.
- 普莱克特-伯曼设计对于优化影响EE和溶解度的变量是有价值的.
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