纳米颗粒在慢性骨髓性白血病治疗中的优势

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Gopalarethinam Janani¹, Agnishwar Girigoswami¹, Koyeli Girigoswami¹

¹Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam, Chennai-603103, India.

|November 8, 2023

概括

纳米技术通过提高测试灵敏度和药物输送来增强早期癌症检测和治疗. 纳米粒子为诊断和治疗慢性髓性白血病 (CML) 和其他癌症提供了优势.

科学领域:

在瘤学瘤学.
纳米医学是一种纳米医学.
生物技术是生物技术.

背景情况:

慢性骨髓性白血病 (CML) 由BCR-ABL融合基因引起,形成费城染色体.
长期性ML的特征是白细胞增加和氨酸激酶活性改变,预后跨越慢性,加速和爆发阶段.
传统的CML诊断方法,如CT扫描和活检,对早期检测有局限性.

研究的目的:

审查纳米技术在诊断和治疗慢性骨髓性白血病 (CML) 中的作用.
探索纳米颗粒如何改善早期癌症检测和药物递送效率.

主要方法:

在PubMed,Scopus和Google Scholar的文献搜索中使用关键词:费城染色体,生物纳米技术,氨酸激酶通路,半衰期,被动准和有机/无机纳米粒子.
选择相关和开创性的论文进行全面的审查.

主要成果:

纳米粒子可以显著提高测试灵敏度和特异性,用于早期癌症检测.
纳米配方增加了药物的半衰期,并促进了免疫系统的逃避,以改善治疗结果.
有机纳米粒子提供良好的生物相容性,而无机纳米粒子延长药物半衰期.

结论:

纳米技术为克服早期CML诊断的局限性提供了一个有希望的方法.
基于纳米粒子的策略对于推进CML治疗和管理至关重要.
该综述强调了各种纳米颗粒在CML治疗中的应用.

关键词:

生物纳米技术是生物纳米技术.半衰期半衰期半衰期被动准是一种被动准.费城染色体是什么意思氨酸激酶途径的氨酸激酶途径

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