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系统性血管动脉瘤和剖析患者中大动脉动脉瘤和剖析的患病率;使用国家样本队列对应的病例控制研究
Jihye Song1, Yong Cheol Lim1, Do Jung Kim2
1Department of Neurosurgery, Ajou University School of Medicine, Ajou University Hospital, Suwon, Republic of Korea.
Frontiers in cardiovascular medicine
|November 8, 2023
概括
患有其他全身血管动脉瘤和解剖 (OVAD) 的患者患有大动脉动脉瘤和解剖 (AAD) 的患病率是大动脉动脉瘤和解剖的37.56倍. 这表明将动脉瘤视为全身性疾病,以便更好地理解和治疗.
科学领域:
- 血管外科 血管外科
- 心血管研究研究心血管研究
- 流行病学 流行病学
背景情况:
- 系统性动脉动脉瘤是罕见的,对它们与大动脉动脉瘤的联系的理解有限.
- 大动脉动脉瘤和解剖 (AAD) 和其他全身血管动脉瘤和解剖 (OVAD) 是不同的,但可能相关的血管疾病.
研究的目的:
- 评估诊断为OVAD的患者中AAD的流行率.
- 确定与AAD和OVAD同时发生相关的潜在风险因素.
主要方法:
- 一项采用韩国国家医疗保险服务-国家样本队列数据库的全国代表队列的横截面研究.
- 定义OVAD为全身血管的动脉瘤和剖析,不包括大脑和大动脉的血管.
- 将690名OVAD患者与2,760名匹配的非OVAD对照进行了比较,使用基平方测试和逻辑回归进行分析.
主要成果:
- 与非OVAD组 (0.3%) 相比,OVAD组的AAD患病率显著更高 (10.6%).
- 患有OVAD的患者对同步AAD的调整后几率比率为37.56.
- 在女性,60岁及以上的个人以及没有高血压,糖尿病或脂质不良症的人群中观察到AAD更高的调整几率比率. 根据OVAD的特定部位,AAD的患病率也发生了显著的变化.
结论:
- 该研究强调了OVAD患者中AAD的患病率大幅增加,这表明动脉瘤可能是全身性疾病.
- 进一步研究动脉瘤的病理生理学是有必要的,以阐明AAD和OVAD之间的关系.
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