酒精和骨肌肉在健康和疾病中的作用
Liz Simon1, Brianna L Bourgeois1, Patricia E Molina1
1Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Alcohol research : current reviews
|November 8, 2023
概括
滥用酒精会通过破坏蛋白质平衡和线粒体功能来损害骨肌肉. 需要进一步的研究来了解与酒精有关的肌肉病变机制,并开发有效的治疗方法.
科学领域:
- 肌肉生理学 肌肉生理学
- 与酒精相关的疾病
背景情况:
- 与酒精有关的肌肉病变是一种早期的病理变化,长期滥用酒精加剧了这种变化.
- 酒精通过多因素机制影响骨肌肉质量和功能.
研究的目的:
- 审查酒精对骨肌肉的急性和慢性影响.
- 为了确定了解酒精介导的骨肌损伤的差距.
主要方法:
- 从2012-2022年对同行评审的手稿进行系统审查.
- 在MEDLINE,PubMed和科学网上搜索了"酒精"或"乙醇"和"骨肌肉".
主要成果:
- 酒精降低蛋白质合成,增加降解,损害肌肉功能.
- 酒精对线粒体的生物能学和细胞外矩阵重塑有负面影响.
结论:
- 在了解酒精对衰老,免疫激活和肌肉病中器官间通信的影响方面存在差距.
- 需要进一步研究患病率,特别是在女性中,以及与衰老,运动和并发性疾病的联合影响.
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