在个体内估计的背侧侧前额叶皮层的并排区域对域特定和域灵活的过程有不同的反应
Lauren M DiNicola1, Wendy Sun2, Randy L Buckner1,3,4
1Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States.
Journal of neurophysiology
|November 8, 2023
概括
前额叶皮层 (PFC) 既有领域灵活的区域,也有领域专业的区域. 一个特定的背侧PFC (DLPFC) 区域支持场景构建,与认知控制区域不同.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
背景情况:
- 神经科学中的一个关键辩论集中在灵长类动物前额叶皮层 (PFC) 是否支持域灵活或域特定的认知过程.
- 了解PFC子区域的功能专业化对于破译复杂的认知功能至关重要.
研究的目的:
- 为了测试这种假设,在PFC内部,不同的并行协会网络包含功能上专门的区域.
- 调查特定的PFC区域是否支持使用功能磁共振成像 (fMRI) 的域灵活与域专用处理.
主要方法:
- 利用9名功能性MRI (fMRI) 患者的密集采样来分析在特异性解剖空间内的大脑活动.
- 已确定与不同网络连接的PFC区域,包括与中叶 (MTL) 连接的背侧PFC (DLPFC) 和与语言网络连接的下方PFC.
- 检查了试验级的反应,以揭示各种任务的功能分离,包括工作记忆,记忆,未来想象力和句子处理.
主要成果:
- 观察到一种功能性三重解离,揭示了已识别的PFC区域的不同作用.
- 连接到MTL的DLPFC区域被专门招募用于记忆,未来想象和场景构建,使其与相邻区域区分开来.
- 连接到语言网络的劣质PFC区域被招募用于句子处理,而其他附近区域在工作记忆期间显示域灵活调制.
结论:
- 背侧PFC (DLPFC) 包含一个用于场景构建的小,域专用区域,传统上与中部叶 (MTL) 相关.
- 这个专门的DLPFC区域在解剖学和功能上与更大,邻近的区域不同,支持域灵活的认知控制.
- 研究结果表明,分离的解剖投影有助于PFC子区域的可分离处理特性,与更广泛的网络区别保持一致.
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