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周血管脂肪组织对微循环的影响:高血压与肥胖之间的联系

Claudia Agabiti-Rosei^1,2, Sophie N Saxton³, Carolina De Ciuceis^1,2

¹Department of Medical and Surgical Sciences, University of Brescia, Italy (C.A.-R., C.D.C., M.L.M., D.R., E.A.R.).

Hypertension (Dallas, Tex. : 1979)

|November 8, 2023

概括

周血管脂肪组织 (PVAT) 功能障碍通过改变微循环,导致肥胖和高血压. 了解这种交叉谈话是开发有针对性的预防和治疗的关键.

科学领域:

心血管科学心血管科学
代谢科学代谢科学
内分泌学在内分泌学.

背景情况:

微循环的改变是心血管和代谢障碍的核心,如肥胖和高血压.
在这些条件下,小阻力动脉表现出重塑,增加相对于光线直径的壁厚,损害器官的血液流动.
周血管脂肪组织 (PVAT) 围绕血管,作为内分泌器官,影响血管度.

研究的目的:

提出一种综合的病理生理学方法来研究微循环和PVAT在肥胖和高血压中的关系.
为了澄清PVAT在这些疾病的发病过程中的作用.
为有效和具体的预防和治疗策略提供基础.

主要方法:

关于PVAT,微循环,肥胖和高血压的当前科学文献的综述.
在不同疾病状态下分析PVAT的分泌特征.
在PVAT和微循环之间相互作用的病理生理学建模.

主要成果:

瘦人体的PVAT分泌着adiponectin,这是一种血管扩展剂,可降低周围抵抗力并改善营养吸收,防止高血压和糖尿病.
在肥胖患者中,PVAT会扩大和炎症,降低阿迪波内克丁的生物可用性,导致周围抵抗性增加和血压升高.
微循环和PVAT之间的交叉对话与肥胖和高血压之间的相互关系有关.

结论:

PVAT在调节血管度方面发挥着重要作用,并与肥胖和高血压的发展有关.
功能障碍的PVAT,其特点是皮质素和炎症的减少,有助于增加周围抵抗力和血压升高.
针对PVAT-微循环轴为肥胖和高血压提供了新的治疗干预措施的潜力.

关键词:

脂肪组织的脂肪组织.动脉小动脉 (arteriole) 是一种动脉小动脉.这种高血压,高血压.这是一种炎症炎症炎症炎症.微循环是一种微循环.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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