医用大麻有助于管理智力障碍者具有挑战性的行为的潜力:一个前景审查
Laura Korb1, Samuel Tromans2,3, Bhathika Perera4,5
1Haringey Learning Disability Partnership, Barnet Enfield and Haringey Mental Health NHS Trust, London, UK.
Journal of psychopharmacology (Oxford, England)
|November 8, 2023
概括
药用大麻 (CBD) 和四大麻 (THC) 显示出对智力障碍者 (PwID) 管理具有挑战性的行为有希望. 需要进一步的研究和联合制作,以克服这种脆弱人群的治疗挑战.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 智力障碍影响大约2%的人口,超过三分之一的人表现出具有挑战性的行为.
- 智力障碍者 (PwID) 具有挑战性的行为是复杂的,受生物心理社会因素的影响,往往导致健康和社会状况不佳.
- 目前,缺乏基于证据的治疗方法来管理PwID中具有挑战性的行为.
研究的目的:
- 审查药用大麻 (CBD) 和四大麻 (THC) 的治疗潜力,以应对PwID中具有挑战性的行为.
- 分析CBD/THC的神经生物学,临床前和临床研究,以发现与具有挑战性的行为相关的疾病.
- 在PwID中综合利用医用大麻的好处和挑战的证据.
主要方法:
- 对近期文学进行视角回顾.
- 神经生物学,临床前和临床研究的分析.
- 综合关于治疗益处和挑战的证据.
主要成果:
- 越来越多的证据表明,药用CBD/THC可以改善精神和行为症状.
- 新出现的证据表明,CBD/THC对具有挑战性的行为产生积极影响,特别是在神经发育障碍中.
- 对于像PwID这样的弱势群体实施这些治疗方法存在重大挑战.
结论:
- 进一步的临床研究对于药用CBD/THC在PwID管理具有挑战性的行为中的使用至关重要.
- 与专家共同制作,包括那些有实践经验的人,对于未来的研究和治疗开发至关重要.
- 医用大麻是一个有希望的,但具有挑战性的领域,可以改善PwID生活的挑战性行为.
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