预测中国北京肥胖儿童胰岛素耐药性的TG/HDL-C比率
Tian Zhang1, Fangfang Duan2, Yi Qian1
1Department of Paediatric Internal Medicine, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Endocrine, metabolic & immune disorders drug targets
|November 8, 2023
概括
甘油三和高脂血糖的比例有效地预测了中国肥胖儿童的胰岛素耐药性. 确定了该比率的特定年龄值,为早期检测提供了有价值的生物标志物.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢综合征研究 代谢综合征研究
- 生物标志物发现发现
背景情况:
- 国际研究将甘油三与高密度脂蛋白胆固醇 (TG/HDL-C) 的比例与超重/肥胖儿童的胰岛素耐药性联系起来.
- 关于这种关联的数据有限,特别是在中国儿科患者中.
研究的目的:
- 调查TG/HDL-C比率作为北京市肥胖儿童胰岛素抵抗 (IR) 生物标志物的实用性.
- 在这个队列中使用TG/HDL-C比率来确定IR的特定年龄的诊断值.
主要方法:
- 一项涉及262名来自儿科门诊的肥胖儿童的横截面研究.
- 数据收集包括病史,临床检查和实验室测试 (血脂,葡萄糖,胰岛素,HbA1c).
- 儿童分为多层次的年龄组 (6-9岁和10-13.5岁),并使用恒温模型评估IR (HOMA-IR) 评估IR.
主要成果:
- 在两个年龄组的IR儿童中,TG/HDL-C比率显著更高 (p < 0.001).
- 在两个年龄层中,TG/HDL-C比率和HOMA-IR之间观察到正相关性 (p <0.05).
- 针对TG/HDL-C比率的特定年龄的截止值显示了中度的诊断准确性 (AUC为0.734在6-9岁和0.724在10-13.5岁).
结论:
- TG/HDL-C比率是北京肥胖儿童胰岛素抵抗的实际预测指标.
- 确定了明显的年龄依赖的值 (≥0.645为6-9岁;≥0.725为10-13.5岁).
- 这些门低于国际上报告的门,表明潜在的种族或环境差异.
关键词:
在HOMA-IR中,我们可以看到HOMA-IR.肥胖问题 肥胖问题在TG/HDL-C比率上.孩子们的孩子们的孩子们的孩子们.高密度的脂蛋白.高密度的脂蛋白.高密度的脂蛋白.胰岛素耐药性是一种胰岛素耐药性.三甲酸甘油三甲酸甘油三甲酸甘油更多相关视频
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