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基因素保留在植物中热应激诱导的转录记忆期间保留表观遗传标记

Loris Pratx¹, Philipp Wendering^2,3, Christian Kappel⁴

¹Plant Epigenetics, Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany.

The EMBO journal

|November 8, 2023

概括

植物通过表观遗传修饰保留热应激记忆. 特定基因的低核细胞周转率维持了基因组甲基化,在重复的热应激事件中提高了生存率.

科学领域:

植物生物学植物生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子生物学分子生物学

背景情况:

植物可以通过热应激 (HS) 进行初始化,以在随后的严重热条件下生存.
这种热应激记忆涉及持续的基因表达和表观遗传修饰,比如素H3氨酸4三甲基化 (H3K4me3).
维持这些表观遗传标记长时间的机制尚不清楚.

研究的目的:

研究植物在热应激后维护表观遗传记忆中的基因组循环的作用.
为了确定热应激记忆基因与非记忆基因之间,基因转换是否有差异.

主要方法:

测量热应激诱导的基因素H3.3的染色质关联,以评估基因素周转率.
对基因组轮流模式的全基因组分析.
在记忆和非记忆基因中,与H3K4me3水平相关联的基因组周转率.

主要成果:

基因组的基因组转换在整个基因组中并不均.
与非记忆基因相比,素H3.3在热应激记忆基因中被保留更长时间.
发现低核细胞周转率维持了H3K4在记忆基因中的甲基化,但甲基化损失没有影响周转率.

结论:

基因组循环调节是保留环境诱导的表观遗传修饰的一个关键机制.
在热应激记忆基因下持续的H3K4甲基化取决于减少的核细胞周转率.
这项研究提供了关于植物记忆和适应环境压力的分子基础的见解.

关键词:

热应激是一种热应激.基因素保留基因素保留希斯顿的营业额启动初始化启动初始化这是转录记忆的转录记忆.

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