在中国老年患者中,欧门丁-1与心力衰竭与保存的喷射分数之间存在关联
Zhengjia Su1, Shuya Tian2, Wei Liang1
1Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Clinical cardiology
|November 8, 2023
概括
老年心力衰竭患者的奥门丁-1水平降低,并与炎症相关. 下奥门丁-1是HFpEF的保护因素,表明其诊断价值.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 生物标志物研究 生物标志物研究
背景情况:
- 奥门丁-1是一种新型阿迪波金,与慢性炎症和心血管疾病有关.
- 在老年人群中,其在心力衰竭中发挥的作用仍然不清楚.
- 这项研究调查了中国老年患者中omentin-1与HFpEF的相关性.
研究的目的:
- 为了确定老年HFpEF患者和对照人群之间是否有差异的奥门丁-1水平.
- 探索omentin-1和HFpEF之间的相关性.
- 评估omentin-1对HFpEF的诊断意义.
主要方法:
- 与酶相关的免疫吸收试验 (ELISA) 用于测量血中的奥门丁-1,TNF-α和IL-6水平.
- 分析了217名受试者 (115名HFpEF患者,102名对照).
- 接收器操作特征 (ROC) 曲线分析评估了omentin-1的诊断性能.
主要成果:
- 与对照组相比,HFpEF患者的奥门丁-1水平明显较低 (14.02对比19.74 ng/mL).
- 在HFpEF患者中,NT-proBNP,IL-6和TNF-α水平升高.
- 奥门-1是E/e'和NT-proBNP的负相关物,也是HFpEF的独立保护因子 (OR=0.948).
- 经过ROC分析表明,omentin-1的诊断AUC与NT-proBNP (0.734对比0.800) 相似.
- 在70-80岁的患者中,欧门丁-1表现出比NT-proBNP更强大的预测能力.
结论:
- 在HFpEF患者下降的奥门丁-1水平与炎症有关.
- 奥门丁-1可以作为一种有价值的生物标志物,用于老年人中HFpEF的发生和进展.
- 进一步的研究可能会阐明omentin-1在HFpEF病理生理学中的确切作用.
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