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影响毒药免疫疗法的安全性和有效性的因素

L Arzt-Gradwohl¹, S A Herzog², W Aberer¹

¹Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

Journal of investigational allergology & clinical immunology

|November 8, 2023

概括

口服抗胰岛素可以减少毒素免疫疗法 (VIT) 期间的大型局部反应,但不能减少系统性不良事件. 毒药制剂在VIT患者中显示出同等的安全性和有效性,而储存形式减少了局部反应.

科学领域:

过敏和免疫学过敏和免疫学
药理学药理学是指药理学的学科.
临床医学临床医学

背景情况:

毒药免疫疗法 (VIT) 的安全性和有效性各不相同,需要对影响因素进行研究.
在VIT中评估特定药物和制剂类型的安全性至关重要.

研究的目的:

在VIT期间评估血管酶转化酶抑制剂和β-抑制剂的安全性.
分析前期治疗和毒药制剂对不良事件 (AE) 和治疗结果的影响.

主要方法:

这是一项开放的,前性的,观察性的多中心研究,涉及1342名接受VIT的患者.
收集了关于前期治疗,毒药制剂,全身性副作用,大型局部反应 (LLR) 和刺痛挑战的数据.

主要成果:

抗组胺前期治疗没有影响系统性副作用,但降低了LLRs (OR,0.74;P=.02).
水性制剂被用于增加剂量 (73.0%) 和储存在维护 (64.5%).
仓库制剂与较少的LLR相关 (P<.001);毒药类型没有影响系统性副作用或疗效.

结论:

口服抗胰岛素在VIT期间有效降低LLR,但不会改变全身AE率.
所有毒药制剂都显示出与系统性AE相比的可比效果和安全性.

关键词:

过敏反应 (ANAPHYLAXIS) 是一种过敏反应.蜜蜂的毒液是蜜蜂的毒液.有效性有效性.药前治疗药前治疗系统性不良事件是系统性的不良事件.毒药免疫疗法是一种毒药免疫疗法.毒药制备剂毒药制备剂这是一种虫毒液.

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