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一种抗生素家族通过结合聚烯酸来逃避抗药性
Adam F Rosenzweig1, Zongqiang Wang1, Adrián Morales-Amador1
1Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States.
ACS infectious diseases
|November 8, 2023
概括
研究人员发现了新的抗生素,paenilagicin和virgilagicin,可以对抗多药耐药的格拉姆阳性细菌. 这些新型抗生素有效地避免了耐药性的发展,提供了一种有希望的新策略来对抗具有挑战性的感染.
科学领域:
- 微生物学 微生物学
- 药物发现 药物发现 药物发现
- 生物信息学是一种生物信息学.
背景情况:
- 抗生素耐药性是一个日益增长的全球健康威胁,特别是针对格拉姆阳性病原体.
- 已知抗生素Cilagicin表现出双聚烯酸结合机制,阻碍了耐药性.
- 识别具有类似耐药阻碍机制的新型抗生素至关重要.
研究的目的:
- 通过生物信息学选非核糖体多合成酶 (NRPS) 编码结构,寻找新型抗生素候选者.
- 识别新的抗生素,像基拉吉一样,可以避免耐药性发展.
- 评估已识别的化合物的生物活性,以对抗多药性耐药性格拉姆阳性病原体.
主要方法:
- 预测NRPS编码结构的生物信息选.
- 已识别的潜在抗生素化合物的化学合成.
- 在体外对抗多种耐药性格拉姆阳性细菌的生物活性查.
- 长期暴露研究以评估耐药性发展.
主要成果:
- 三种新型抗生素化合物被确定并合成.
- 这三种化合物都表现出对抗多药耐药性格拉姆阳性病原体的活性.
- 两个化合物,paenilagicin和virgilagicin,即使在长时间暴露于抗生素后,也没有显示出耐药性的发展.
结论:
- 生物信息查方法成功识别了新型抗生素候选者.
- 帕尼拉基和维吉拉基是有希望的新型抗生素,具有克服耐药性的机制.
- 这些发现为对抗由多抗药性格拉姆阳性细菌引起的感染提供了潜在的新途径.
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