在美国,艾滋病毒暴露前预防的坚持和持续使用
Carter D McCormick1, Patrick S Sullivan2, Dima M Qato3,4
1Department of Pharmacy Systems, Outcomes and Policy, University of Illinois Chicago, College of Pharmacy, Chicago, Illinois, USA.
Pharmacoepidemiology and drug safety
|November 8, 2023
概括
对于艾滋病毒暴露前预防 (PrEP) 的药物坚持通常在保险人员中很高,但大多数人在一年内停止治疗. 需要进一步的研究来了解和解决戒断障碍.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 药学流行病学 药学流行病学
背景情况:
- 艾滋病毒暴露前预防 (PrEP) 是预防艾滋病毒的关键生物医学干预措施.
- 了解药物坚持和持续性对于评估PrEP的实际有效性至关重要.
- 性别和年龄是可能影响坚持和坚持模式的人口统计因素.
研究的目的:
- 为了确定美国商业保险人群中HIV PrEP的整体药物坚持和持久率.
- 在这个人群中,在不同性别和年龄组之间比较PrEP的坚持和持久性.
主要方法:
- 从2011年到2019年使用Merative MarketScan索赔数据库进行了一项回顾性队列研究.
- 坚持被定义为至少达到80%的覆盖日数 (PDC).
- 持续性被测量为从开始治疗到60天治疗间隔的时间.
主要成果:
- 在29,689名新的PrEP使用者中观察到高整体坚持 (81.9%).
- 与男性相比,女性表现出较高的坚持率 (aOR1.87),但持久率较低 (HR1.49).
- 45岁及以上的个体表现出较低的坚持率 (aOR 0.87),但比45岁以下的个体表现出更高的持久率 (HR 0.43).
结论:
- 在商业保险人口中,每日PrEP的坚持是相当大的,但大多数人在第一年内停止使用.
- 性别和年龄段之间在坚持和持久性方面存在显著差异.
- 调查影响PrEP停药的因素,并制定改善治疗维持的策略,对于最大限度地提高人口层面的艾滋病毒预防效益至关重要.
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