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耐空气的卡迪奥特-乔德基维奇和索诺加希拉交叉合器
Alfred K K Fung1, Madison J Sowden1, Michelle L Coote2
1Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory2601, Australia.
Organic letters
|November 8, 2023
概括
这项研究引入了酸盐作为减少剂,以改善Cadiot-Chodkiewicz交叉合,最大限度地减少不必要的副产品. 这种方法可以实现高产量,近乎立体比率,并避免恶劣的条件,增强diyne合成.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 卡迪奥-乔德基维奇交叉合对于合成不对称的buta-1,3-diyne至关重要.
- 这些反应往往受到对称的布塔-1,3-二烯副产物的影响,需要大量的反应剂过剩和困难的净化.
研究的目的:
- 为卡迪奥特-乔德基维奇交叉合开发一种更有效,更可持续的方法.
- 为了抑制不必要的同性伴侣副产品的形成.
主要方法:
- 在Cu(I) 催化卡迪奥特-乔德基维奇反应中使用酸盐作为还原剂.
- 在Pd(0)/Pd(II) 催化交叉合器,包括索诺加希拉合器中,应用类似的甲酸盐介导方法.
主要成果:
- 实现了对称的buta-1,3-diyne副作用的显著抑制.
- 通过使用反应剂的近立体比率获得了出色的产量.
- 该过程证明了对空气的耐受性,并使用了可持续的溶剂,避免了需要惰性大气的需要.
结论:
- 亚斯科伯酸盐通过将副作用降到最低,有效地增强了卡迪奥-乔德基维奇和相关的交叉合反应.
- 这种方法为diyne合成提供了一个更绿色,更有效,更实用的替代方案.
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