侵袭性融合症是一种侵袭性融合症
Marcio Nucci1,2, Elias Anaissie3
1University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Clinical microbiology reviews
|November 8, 2023
概括
侵入性菌病是一种严重的真菌感染,影响健康和免疫受损的个体. 患者的康复取决于管理潜在的免疫抑制,特别是中性衰竭患者中性粒细胞的恢复.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 侵入性菌病是一种严重的真菌感染,具有显著的发病率和死亡率.
- 它既影响免疫能力强,更常见的是免疫功能低下的患者.
- 接受化疗的急性白血病患者和全原造血细胞移植接受者具有高风险.
研究的目的:
- 总结入侵性菌病的临床表现和治疗方法.
- 为了突出治疗这种感染现有抗真菌剂的挑战.
- 强调宿主免疫恢复在患者结果中的关键作用.
主要方法:
- 临床文献对侵袭性疹病的综述.
- 对有关风险因素和结果的患者数据的分析.
- 讨论抗真菌敏感性和临床疗效.
主要成果:
- 在免疫能力强的患者中,这种疾病通常局部化.
- 在免疫受损的宿主中,感染往往传播,涉及皮肤和肺部,具有阳性血液培养.
- 目前的抗真菌药物在体外对Fusarium的活性有限,临床相关性不确定.
结论:
- 侵袭性菌病的结果与免疫抑制的解决密切相关.
- 中性粒细胞的恢复对于中性粒细胞衰竭患者尤为重要.
- 有效的管理需要解决真菌感染和宿主的免疫状态.
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