在暴露于的工人中,高达6年的血压和功能反应
Yu-Ling Yu1,2, De-Wei An1,2,3, Wen-Yi Yang4
1Research Unit Environment and Health, KU Leuven Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium.
Journal of clinical hypertension (Greenwich, Conn.)
|November 8, 2023
概括
这项研究发现,回收工人血液中含量增加在六年内没有显著影响血压或功能. 现代安全措施在防止暴露对健康造成不良影响方面显得有效.
科学领域:
- 职业健康 职业健康 职业健康
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 职业暴露对心血管和健康构成风险.
- 评估循环行业工人暴露于的长期健康影响至关重要.
- 了解对血压和功能的影响对于工人的安全至关重要.
研究的目的:
- 为了评估血中含量增加对没有先前职业暴露的工人的血压和功能的影响.
- 评估现代处理设施的安全性,按照当前的安全法规运行.
主要方法:
- 在回收中促进健康的研究 (SPHERL) 追踪了234名工人长达6年.
- 血压和功能 (eGFRcrt,eGFRcys) 被监测.
- 使用诱导合血质谱法测量血液中的含量.
- 统计分析包括多变量调整混合模型和间隔审查的考克斯回归.
主要成果:
- 在随访期间,血液中的含量增加了3倍以上.
- 血压和功能变化与血水平比率没有显著相关.
- 血的翻倍与静缩/腹缩血压 (-0.25/-0.12毫米) 的最小,无意义的变化有关.
- 血增加的3倍显示了eGFRcrt (-0.70毫升/分钟/1.73米2) 和eGFRcys (-1.06毫升/分钟/1.73米2) 的非显著变化.
- 没有发现血变化与1或2阶段高血压发病率之间有显著的关联.
结论:
- 血压和功能对血水平显著增加的反应很小,并且没有统计学意义.
- 这些发现表明,按照当前的安全规则运行的现代处理设施对工人来说是安全的.
- 该研究证实了当前安全协议在减轻循环行业中与有关的健康风险方面的有效性.
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