患有间歇性肺部疾病的多聚质炎/皮质炎患者的炎症生物标志物:一项回顾性研究
Jin Zhao1,2,3, Xiao-Jing Guo1,2,3, Lei Shi4
1Department of Hematology, Shanxi Province Cancer Hospital, Taiyuan, Shanxi, China.
Current medical research and opinion
|November 8, 2023
概括
皮质神经炎/多聚神经炎患者的间歇性肺部疾病显示了淋巴细胞子集的改变,特别是较低调节性T细胞. 这些发现有助于评估DM/PM中的肺部参与.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
背景情况:
- 皮质神经炎 (DM) /多神经炎 (PM) 是一种全身性自身免疫性疾病,病因不明.
- 这些情况带有间歇性肺病 (ILD) 和死亡率的高风险.
- 在ILD的DM/PM中循环淋巴细胞子集的作用仍然不清楚.
研究的目的:
- 调查外围血液淋巴细胞子集与DM/PM患者的ILD之间的关联.
- 确定DM/PM中肺部参与的潜在生物标志物.
主要方法:
- 流细胞计用于分析47名患有ILD的DM/PM患者,65名没有ILD的DM/PM患者和105名健康对照者的淋巴细胞子集.
- 收集和分析了人口统计和临床数据.
主要成果:
- 与非ILD患者相比,DM/PM患者的中性细胞/淋巴细胞比率 (NLR) 和全身炎症反应指数 (SIRI) 较高,C反应蛋白 (CRP) 较低.
- 与健康对照组相比,患有DM/PM,有或没有ILD的患者表现出T细胞,CD4+T细胞,CD8+T细胞,NK细胞,Th1,Th2,Th17和Treg细胞数量下降.
- 在ILD患者的外周血液中,Th1和Treg细胞以及CD8+T细胞的百分比最低.
- 较低的淋巴细胞/单细胞比率 (LMR),CD8+ T细胞,Th1细胞和较少的Treg细胞是DM/PM与ILD的独立风险因素.
结论:
- 周围血液T淋巴细胞子集,特别是调节性T (Treg) 细胞,在患有ILD的DM/PM患者中发生显著变化.
- 测量这些淋巴细胞子集和血细胞计数可以帮助全面评估DM/PM中的肺部参与.
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