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Updated: Jun 28, 2026

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使用Css-MRTpo方法和带有人性化的肝脏的奇默小鼠预测不成比例代谢物的人类药理学概况的实证缩放因子

Hidetaka Kamimura1, Shotaro Uehara1, Nao Yoneda1

  • 1Department of Applied Research for Laboratory Animals, Central Institute for Experimental Medicine and Life Science, Kawasaki, Japan.

Xenobiotica; the fate of foreign compounds in biological systems
|November 8, 2023
PubMed
概括

预测人类药物代谢物的药理动力学至关重要. 用人性化仿真小鼠进行的Css-MRTpo方法显示出预测不成比例的代谢物有前途,改善了早期药物开发安全性评估.

关键词:
CssMRTpo方法的方法奇默的老鼠 奇默的老鼠 奇默的老鼠不成比例的代谢物.人性化肝脏的人性化肝脏血度时间概况.

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