针对有呼吸道感染的ICU患者的常规元基因组学服务
Themoula Charalampous1, Adela Alcolea-Medina1,2, Luke B Snell1,3
1Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, School of Immunology and Microbial Sciences and.
American journal of respiratory and critical care medicine
|November 8, 2023
概括
呼吸系统转基因组学 (RMg) 在重症监护中表现有前途,提供快速的结果,指导抗微生物药物处方和感染控制. 这项试点研究突出了RMgg的重点.
科学领域:
- 临床微生物学 临床微生物学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 呼吸系统转基因组学 (RMg) 需要在服务环境中进行评估,以评估其临床实用性.
- 在日常实践中实施需要了解可行性,性能和临床影响.
研究的目的:
- 评估一个试点呼吸系统转基因组学 (RMg) 服务的可行性,性能和临床影响.
- 评估RMg在下呼吸道感染 (LRTI) 中对抗菌素处方和感染控制的影响.
主要方法:
- 呼吸系统转基因组学 (RMg) 对来自87名疑似LRTI患者的128个样本进行了测试.
- 这项研究是在一般和专业的呼吸器重症监护室 (ICU) 进行的.
- 记录了可行性,周转时间,灵敏度,特异性和对治疗的影响.
主要成果:
- RMg为86%的样本提供了当天的结果,平均周转时间为6.7小时.
- 对于临床相关的病原体,RMg表现出93%的灵敏度和81%的特异性.
- 48%的RMg结果导致了抗微生物药物处方的变化,包括基于病原体识别和耐药基因的缓和和升级. 发现了意想不到的生物和毒性因素,影响了治疗和公共卫生.
结论:
- 在重症监护机构的试点RMg测试显示了对抗微生物治疗,感染控制和公共卫生的潜在益处.
- 需要进一步的多中心研究来支持将RMg转化为常规临床服务.
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