Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Brick Sizes01:21

Brick Sizes

99
Brick sizing plays a crucial role in construction, influencing both the aesthetics and structural integrity of buildings. Bricks are defined by three dimensions: width, thickness, and length. They are commonly designed to fit modular measurements, typically in multiples of 4 inches or 8 inches in width, to facilitate uniform construction and compatibility with other building materials.
Modular bricks are the most common type and are sized to include the mortar joint, which is essential for...
99
Bricks01:14

Bricks

98
Bricks, a fundamental building material, are crafted from fired clay and exhibit a range of shapes, sizes, and colors. The production process starts with extracting local clay or shale, which is then crushed, ground, and screened for a fine texture. The refined material is blended with water, creating a pliable mixture that can be formed into bricks using one of three processes: soft mud, dry press, or stiff mud methods.
Soft mud bricks are shaped in molds with high moisture content and can be...
98
Social Proof00:52

Social Proof

27.7K
Social proof is a form of persuasion based on comparison and conformity. People compare their behavior and actions to what others are doing and will change to conform to do what their peers do.
27.7K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.2K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.2K
Brick Durability, Strength, and Appearance01:15

Brick Durability, Strength, and Appearance

217
Brick durability, strength, and appearance are crucial factors in construction, influencing the choice of bricks for specific applications. The process of freeze-thaw, for instance, significantly affects brick durability. This phenomenon occurs when water absorbed by a brick expands as it freezes, potentially causing damage when it melts and refreezes. Bricks are graded for durability: SW-grade bricks are the most durable, offering high strength and low water absorption, followed by MW-grade...
217
Self-Presentation: Self-Monitoring and Self-Handicapping02:05

Self-Presentation: Self-Monitoring and Self-Handicapping

39.0K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
39.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Ca<sub>V</sub>1.2 dynamics in native male arterial myocytes.

The Journal of physiology·2026
Same author

Exploration of NMDA and GABA receptor-mediated plasticity induced by 10-Hz repetitive transcranial magnetic stimulation.

Translational psychiatry·2026
Same author

State-specific inhibition of NMDA receptors by memantine provides insight into NMDAR channel blocker tolerability.

Science advances·2026
Same author

Circuit-Targeted TMS for PTSD: Where, When, How, and for Whom?

The American journal of psychiatry·2026
Same author

Context-Dependent Control: PKA Regulation of Vascular Ca<sub>V</sub>1.2 Requires S1928 not Rad Phosphorylation.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Redox-Activated Probes Enable High-Contrast Live Imaging of Native Postsynaptic Scaffolds.

Angewandte Chemie (International ed. in English)·2026
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
查看所有相关文章

相关实验视频

Updated: Jul 11, 2025

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
07:56

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure

Published on: September 19, 2019

10.0K

吹嘘关于 (s) 彩票的情况.

Joshua C Brown1,2, Johannes W Hell3, Nashaat Z Gerges4

  • 1Division of Depression and Anxiety Disorders, Brain Stimulation Mechanisms Laboratory, McLean Hospital, Belmont, MA, USA.

The Journal of cell biology
|November 8, 2023
PubMed
概括
此摘要是机器生成的。

在IQSEC2/BRAG1中的突变通过影响ARF-GEF活动来破坏大脑功能. 一项新的研究显示,Ca2+调节了这种蛋白质.

更多相关视频

Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community
08:53

Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community

Published on: May 31, 2019

5.2K
The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory
07:26

The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory

Published on: January 31, 2017

38.1K

相关实验视频

Last Updated: Jul 11, 2025

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
07:56

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure

Published on: September 19, 2019

10.0K
Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community
08:53

Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community

Published on: May 31, 2019

5.2K
The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory
07:26

The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory

Published on: January 31, 2017

38.1K

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • IQSEC2/BRAG1中的突变与智力功能障碍有关.
  • 蛋白质IQSEC2/BRAG1充当ARF-GEF,对突触可塑性至关重要.
  • 长期抑郁障碍 (LTD) 是受影响认知功能的标志.

研究的目的:

  • 阐明IQSEC2/BRAG1组成的ARF-GEF活动的监管机制.
  • 了解Ca2+如何影响IQSEC2/BRAG1的形状和功能.
  • 研究致病突变对蛋白质活性和认知表现的影响.

主要方法:

  • 生物化学试验研究ARF-GEF活动.
  • 结构生物学技术用于确定蛋白质构成.
  • 电生理学记录以评估突触功能.
  • 评估认知表现的行为测试.

主要成果:

  • IQSEC2/BRAG1存在于一个封闭的,自抑制的形状.
  • 离子 (Ca2+) 诱导结构变化,打开蛋白质并激活ARF-GEF.
  • 致病突变导致"漏洞"的自身抑制,减少突触活动的动态范围.
  • 这些分子缺陷与认知能力受损相关.

结论:

  • IQSEC2/BRAG1活动受到Ca2+依赖的形状变化的严格调节.
  • 致病性IQSEC2/BRAG1突变通过改变ARF-GEF调节损害了突触可塑性和认知功能.
  • 这项研究为了解IQSEC2/BRAG1相关的智力功能障碍提供了分子基础.