皮质上与皮质外的角膜原交叉连接对于角膜:一个系统的审查和元分析
Grace A Borchert1, Himal Kandel2, Stephanie L Watson2
1The University of Sydney, Save Sight Institute, Sydney, New South Wales, Australia. gbor0882@uni.sydney.edu.au.
概括
皮质外和皮质上角膜原交联 (CXL) 两种疗法都有效治疗渐进性角质. 虽然这两种方法都显示出类似的视力敏度和角膜曲率结果,但上皮外CXL显示出未经纠正的视力和角膜稀薄的轻微改善.
科学领域:
- 眼科医生 眼科 眼科
- 角膜外科手术 角膜外科手术
- 视觉科学 视觉科学 视觉科学
背景情况:
- 渐进式角明显损害视力和生活质量.
- 角膜原交联 (CXL) 是渐进性角膜的标准治疗方法.
- 将上皮质与外皮质CXL进行比较对于优化治疗策略至关重要.
研究的目的:
- 为了比较表皮在线与表皮离线CXL在治疗角质的疗效和安全性.
- 在CXL程序后评估视觉敏度和角膜指标.
- 确定两种CXL方法之间的结果和不良事件的潜在差异.
主要方法:
- 对比CXL上皮质和外皮质的研究的系统审查和元分析.
- 搜索了包括PubMed,Medline,Embase,Web of Science和Scopus在内的主要科学数据库.
- 主要结局:纠正距离视敏度 (CDVA) 和最大角质量测量 (Kmax);次要结局:未纠正距离视敏度 (UDVA) 和中角膜厚度 (CCT).
主要成果:
- 分析包括来自1399名患者的1622只眼睛.
- 在12个月的随访期间,在表皮外和表皮上CXL之间没有观察到CDVA或Kmax的显著差异.
- 与表皮上CXL相比,表皮上CXL显示了UDVA的统计学上显著改善和更大的CCT稀释.
结论:
- 表皮脱落和表皮在CXL上的两种疗法都是治疗渐进性角质的有效方法.
- 需要进一步的研究来确定临床实践的长期结果和安全性.
- 选择CXL协议之间的选择可能取决于特定的患者因素和预期的结果.
相关概念视频
Mechanisms of Membrane Domain Formation
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Integrins
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Anchoring Junctions
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
Overview of Cell-Cell Junctions
The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another cell. These cell junctions are classified into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight Junctions
Tight...
Occluding or Tight Junctions
Tight...
Tight Junctions
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Tissue Membranes
A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...


