三十年来,急性淋巴细胞白血病和非霍奇金淋巴瘤幸存者的身体功能趋势
Carmen L Wilson1, Kari L Bjornard2, Robyn E Partin3
1Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA. carmen.wilson@stjude.org.
Journal of cancer survivorship : research and practice
|November 8, 2023
概括
患有急性淋巴细胞白血病 (ALL) 和非霍奇金淋巴瘤 (NHL) 的儿童癌症幸存者经历了持续的身体能力限制. 尽管治疗方法不断发展,但功能性缺陷从20世纪70年代到90年代保持不变.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症的生存率 癌症的生存率
- 康复医学 康复医学 康复医学
背景情况:
- 儿童急性淋巴细胞白血病 (ALL) 和非霍奇金淋巴瘤 (NHL) 的治疗进展旨在改善治疗结果.
- 这些不断发展的疗法对幸存者的身体功能的长期影响仍然不完全理解.
研究的目的:
- 确定儿童ALL和NHL幸存者的身体性能限制和参与限制的流行情况.
- 分析这些功能性结果在不同的治疗时代.
主要方法:
- 利用了儿童癌症幸存者研究 (CCSS) 的数据,将幸存者 (N=6511) 与他们的兄弟姐妹 (N=4127) 进行了比较.
- 通过问卷评估身体功能,并比较幸存者和兄弟姐妹之间限制的流行率.
- 按治疗十年 (1970年代,1980年代,1990年代) 分层分析,并检查慢性疾病与功能之间的关联.
主要成果:
- 与兄弟姐妹相比,幸存者表现出显著更高的性能限制,个人护理限制,日常活动困难和工作/上学时间限制的风险.
- 幸存者的身体功能减弱的患病率在20世纪70年代到90年代之间没有下降.
- 神经和心血管慢性疾病始终与功能减弱有关.
结论:
- 尽管癌症治疗方案发生了变化,但儿童ALL和NHL幸存者的身体功能限制负担仍然稳定.
- 研究结果强调,需要对癌症幸存者的身体功能减弱进行系统查,以便及时进行干预.
- 早期干预可能会改善身体表现,减轻慢性疾病的影响.
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